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Rev. Soc. Bras. Med. Trop ; 31(3): 249-255, maio-jun. 1998. graf, tab
Article in Portuguese | LILACS | ID: lil-463672

ABSTRACT

Pacientes na fase crônica da doença de Chagas foram tratados com corticóide em virtude de afecções associadas e, a fim de tentar coibir reativação da infecção pelo Trypanosoma cruzi, houve uso concomitante do nifurtimox. Levando em conta o verificado em pesquisa anterior, quando corticóide de fato promoveu aumento da parasitemia detectada pelo xenodiagnóstico, pôde ser notado que o nifurtimox mostrou-se apto a evitar a citada acentuação parasitária, podendo tal constatação ser útil em procedimentos assistenciais, quando circunstancialmente estiverem presentes doença de Chagas e imunodepressão.


Patients in the chronic phase of Chagas' disease and receiving corticoid because of concommitant diseases were treated with nifurtimox. We proved in another paper that in the chronic phase of Chagas' disease corticoid use is associated with increased parasitemia, as evaluated by xenodiagnosis. In this study nifurtimox use prevented this increase, and we suggest that in immunocompromised patients with chronic Chagas' disease the use of this drug could be useful.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Antiparasitic Agents/therapeutic use , Chagas Disease/drug therapy , Glucocorticoids/therapeutic use , Nifurtimox/therapeutic use
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